Click on the table headers to sort. Stats are explained at the Advanced NFL Stats glossary page.
| Rank | Player | Team | G | +WPA | +EPA | +EPA/G | SC | Tkl | Asst | TF | Sk | SkYd | PD | QBHit | FF | TklLoss | Int |
| 1 | 90-D.Dockett | ARZ | 16 | 1.97 | 47.1 | 2.94 | 46 | 35 | 16 | 0.89 | 4 | 30 | 1 | 16 | 1 | 10 | 0 |
| 2 | 94-J.Smith | SF | 18 | 1.96 | 46.2 | 2.57 | 59 | 54 | 14 | 1.16 | 9 | 63 | 2 | 28 | 3 | 8 | 0 |
| 3 | 97-G.Atkins | CIN | 17 | 1.53 | 58.7 | 3.45 | 53 | 29 | 22 | 0.85 | 10 | 48 | 3 | 16 | 2 | 11 | 0 |
| 4 | 92-H.Ngata | BLT | 18 | 1.42 | 55.5 | 3.08 | 70 | 39 | 32 | 1.10 | 5 | 21 | 6 | 10 | 3 | 6 | 0 |
| 5 | 75-V.Wilfork | NE | 18 | 1.31 | 49.7 | 2.76 | 53 | 35 | 28 | 0.88 | 6 | 33 | 3 | 11 | 1 | 10 | 2 |
| 6 | 91-R.McDonald | SF | 15 | 1.17 | 36.0 | 2.40 | 41 | 32 | 11 | 0.88 | 10 | 56 | 2 | 10 | 3 | 7 | 0 |
| 7 | 98-P.Taylor | CLV | 15 | 1.11 | 29.4 | 1.96 | 39 | 37 | 22 | 1.08 | 4 | 14 | 1 | 6 | 1 | 6 | 0 |
| 8 | 99-C.Canty | NYG | 19 | 1.09 | 27.3 | 1.44 | 47 | 33 | 19 | 0.74 | 4 | 20 | 3 | 8 | 0 | 12 | 0 |
| 9 | 90-N.Suh | DET | 15 | 1.09 | 33.1 | 2.21 | 36 | 26 | 13 | 0.72 | 5 | 34 | 1 | 11 | 0 | 6 | 0 |
| 10 | 97-L.Joseph | NYG | 19 | 1.08 | 30.8 | 1.62 | 53 | 40 | 20 | 0.85 | 2 | 15 | 5 | 6 | 0 | 5 | 0 |
| 11 | 71-A.Rubin | CLV | 16 | 0.95 | 27.8 | 1.74 | 56 | 55 | 27 | 1.41 | 6 | 37 | 0 | 12 | 0 | 4 | 0 |
| 12 | 97-C.Jenkins | PHI | 15 | 0.95 | 32.0 | 2.13 | 37 | 33 | 7 | 0.83 | 6 | 27 | 0 | 11 | 0 | 11 | 0 |
| 13 | 94-D.Peko | CIN | 16 | 0.92 | 23.6 | 1.48 | 49 | 38 | 32 | 1.23 | 3 | 19 | 0 | 5 | 1 | 6 | 0 |
| 14 | 90-J.Ratliff | DAL | 15 | 0.89 | 30.3 | 2.02 | 33 | 29 | 9 | 0.77 | 2 | 9 | 3 | 6 | 0 | 8 | 0 |
| 15 | 99-J.Casey | TEN | 16 | 0.87 | 27.9 | 1.74 | 46 | 40 | 13 | 0.91 | 3 | 16 | 1 | 7 | 1 | 7 | 0 |
| 16 | 91-S.Pouha | NYJ | 15 | 0.86 | 38.5 | 2.57 | 54 | 41 | 16 | 1.19 | 1 | 11 | 3 | 1 | 1 | 5 | 0 |
| 17 | 71-A.Garay | SD | 16 | 0.84 | 20.4 | 1.28 | 42 | 37 | 20 | 1.01 | 3 | 10 | 0 | 7 | 0 | 6 | 0 |
| 18 | 99-M.Dareus | BUF | 16 | 0.84 | 28.9 | 1.81 | 36 | 32 | 11 | 0.71 | 6 | 33 | 1 | 8 | 0 | 9 | 0 |
| 19 | 79-M.Thomas | DEN | 14 | 0.78 | 26.6 | 1.90 | 43 | 31 | 16 | 0.93 | 0 | 0 | 1 | 1 | 0 | 4 | 0 |
| 20 | 93-T.Kelly | OAK | 16 | 0.77 | 28.0 | 1.75 | 39 | 27 | 14 | 0.77 | 8 | 34 | 5 | 11 | 2 | 3 | 1 |
| 21 | 93-T.Alualu | JAX | 14 | 0.73 | 23.8 | 1.70 | 35 | 21 | 19 | 0.81 | 3 | 9 | 1 | 8 | 1 | 3 | 0 |
| 22 | 90-I.Sopoaga | SF | 12 | 0.72 | 18.8 | 1.57 | 35 | 23 | 11 | 0.87 | 0 | 0 | 0 | 3 | 0 | 1 | 0 |
| 23 | 99-A.Branch | SEA | 14 | 0.69 | 16.3 | 1.16 | 29 | 21 | 13 | 0.67 | 3 | 18 | 1 | 3 | 0 | 5 | 0 |
| 24 | 92-B.Mebane | SEA | 15 | 0.67 | 26.9 | 1.79 | 45 | 40 | 16 | 1.03 | 0 | 0 | 1 | 4 | 0 | 7 | 0 |
| 25 | 77-B.Bunkley | DEN | 15 | 0.61 | 25.6 | 1.71 | 40 | 37 | 12 | 0.90 | 1 | 6 | 0 | 2 | 1 | 4 | 0 |
| 26 | 98-M.Patterson | PHI | 15 | 0.61 | 25.4 | 1.69 | 29 | 26 | 9 | 0.73 | 3 | 20 | 0 | 3 | 1 | 6 | 0 |
| 27 | 91-C.Peters | ATL | 13 | 0.57 | 29.0 | 2.23 | 30 | 22 | 5 | 0.62 | 3 | 29 | 3 | 6 | 0 | 7 | 1 |
| 28 | 93-K.Williams | MIN | 13 | 0.55 | 18.2 | 1.40 | 30 | 24 | 13 | 0.77 | 5 | 34 | 2 | 9 | 1 | 9 | 0 |
| 29 | 95-R.Bernard | NYG | 17 | 0.50 | 15.4 | 0.91 | 29 | 21 | 17 | 0.60 | 1 | 8 | 3 | 2 | 1 | 1 | 0 |
| 30 | 99-C.Williams | DET | 15 | 0.50 | 13.8 | 0.92 | 24 | 22 | 11 | 0.61 | 3 | 12 | 1 | 6 | 0 | 3 | 0 |
| 31 | 92-R.Seymour | OAK | 12 | 0.47 | 18.3 | 1.53 | 30 | 22 | 6 | 0.70 | 6 | 23 | 3 | 10 | 0 | 4 | 0 |
| 32 | 69-L.Douzable | JAX | 14 | 0.45 | 20.6 | 1.47 | 33 | 22 | 16 | 0.77 | 1 | 8 | 1 | 5 | 0 | 6 | 0 |
| 33 | 74-K.Love | NE | 18 | 0.41 | 24.4 | 1.36 | 39 | 23 | 18 | 0.57 | 4 | 18 | 1 | 7 | 0 | 5 | 0 |
| 34 | 98-R.McBean | DEN | 14 | 0.40 | 21.7 | 1.55 | 28 | 23 | 15 | 0.75 | 4 | 10 | 0 | 5 | 0 | 9 | 0 |
| 35 | 79-J.Henderson | OAK | 13 | 0.40 | 18.2 | 1.40 | 31 | 24 | 10 | 0.79 | 0 | 0 | 4 | 1 | 0 | 0 | 0 |
| 36 | 62-T.Cody | BLT | 13 | 0.40 | 14.4 | 1.11 | 36 | 24 | 18 | 0.90 | 0 | 0 | 1 | 0 | 0 | 3 | 0 |
| 37 | 77-K.Gregg | KC | 13 | 0.39 | 11.5 | 0.88 | 31 | 24 | 14 | 0.85 | 1 | 10 | 1 | 1 | 0 | 2 | 0 |
| 38 | 69-C.McDonald | SEA | 14 | 0.38 | 14.1 | 1.01 | 26 | 21 | 14 | 0.69 | 0 | 0 | 0 | 4 | 0 | 1 | 0 |
| 39 | 95-J.Bannan | SL | 12 | 0.38 | 13.6 | 1.13 | 28 | 25 | 6 | 0.73 | 0 | 0 | 2 | 1 | 0 | 4 | 0 |
| 40 | 98-F.Robbins | SL | 14 | 0.31 | 13.6 | 0.97 | 23 | 21 | 8 | 0.59 | 1 | 0 | 2 | 1 | 0 | 4 | 0 |
