Click on the table headers to sort. Stats are explained at the Advanced NFL Stats glossary page.
| Rank | Player | Team | G | WPA | EPA | WPA/G | EPA/P | SR(%) | Att | Cmp | Cmp% | PassYds | Sk | SkYds | Int | %Deep | AYPA |
| 1 | 9-D.Brees | NO | 17 | 4.88 | 160.3 | 0.29 | 0.21 | 52.6 | 718 | 487 | 67.8 | 5024 | 26 | 192 | 22 | 16.0 | 5.2 |
| 2 | 2-M.Ryan | ATL | 17 | 4.54 | 105.2 | 0.27 | 0.15 | 48.0 | 600 | 377 | 62.8 | 3891 | 28 | 195 | 11 | 20.7 | 5.1 |
| 3 | 12-A.Rodgers | GB | 19 | 4.45 | 179.1 | 0.23 | 0.24 | 53.1 | 607 | 402 | 66.2 | 5016 | 39 | 246 | 13 | 23.1 | 6.5 |
| 4 | 5-J.Flacco | BLT | 18 | 3.20 | 74.7 | 0.18 | 0.11 | 45.4 | 553 | 347 | 62.7 | 4012 | 49 | 345 | 11 | 24.1 | 5.3 |
| 5 | 12-T.Brady | NE | 17 | 3.17 | 148.1 | 0.19 | 0.24 | 50.4 | 537 | 353 | 65.7 | 4199 | 30 | 215 | 5 | 14.3 | 6.6 |
| 6 | 18-P.Manning | IND | 17 | 3.11 | 147.9 | 0.18 | 0.20 | 52.9 | 706 | 468 | 66.3 | 4925 | 17 | 97 | 17 | 21.0 | 5.6 |
| 7 | 5-J.Freeman | TB | 16 | 3.10 | 101.0 | 0.19 | 0.17 | 47.0 | 474 | 291 | 61.4 | 3451 | 28 | 195 | 6 | 21.7 | 5.9 |
| 8 | 9-D.Garrard | JAX | 14 | 2.42 | 50.2 | 0.17 | 0.10 | 48.1 | 366 | 236 | 64.5 | 2734 | 32 | 251 | 15 | 21.6 | 4.5 |
| 9 | 6-M.Sanchez | NYJ | 18 | 2.31 | 32.1 | 0.13 | 0.05 | 43.7 | 596 | 332 | 55.7 | 3907 | 30 | 190 | 14 | 21.3 | 4.9 |
| 10 | 7-B.Roethlisberger | PIT | 15 | 2.14 | 133.8 | 0.14 | 0.23 | 48.5 | 480 | 294 | 61.3 | 3822 | 41 | 269 | 9 | 26.3 | 6.0 |
| 11 | 8-M.Schaub | HST | 16 | 2.02 | 119.3 | 0.13 | 0.18 | 49.2 | 574 | 365 | 63.6 | 4369 | 32 | 226 | 12 | 16.9 | 5.9 |
| 12 | 17-P.Rivers | SD | 16 | 2.02 | 140.9 | 0.13 | 0.22 | 50.1 | 541 | 357 | 66.0 | 4710 | 38 | 227 | 13 | 21.8 | 6.7 |
| 13 | 10-E.Manning | NYG | 16 | 1.75 | 63.3 | 0.11 | 0.10 | 49.3 | 539 | 339 | 62.9 | 4002 | 16 | 117 | 25 | 24.5 | 5.0 |
| 14 | 7-M.Vick | PHI | 13 | 1.53 | 111.0 | 0.12 | 0.20 | 48.6 | 408 | 253 | 62.0 | 3310 | 38 | 233 | 7 | 22.3 | 6.2 |
| 15 | 1-T.Smith | SF | 6 | 1.34 | 8.1 | 0.22 | 0.04 | 41.5 | 145 | 73 | 50.3 | 1176 | 18 | 112 | 4 | 27.6 | 5.4 |
| 16 | 8-J.Campbell | OAK | 13 | 1.28 | 51.9 | 0.10 | 0.12 | 42.1 | 329 | 194 | 59.0 | 2387 | 33 | 208 | 8 | 22.2 | 5.0 |
| 17 | 7-M.Cassel | KC | 16 | 1.18 | 64.1 | 0.07 | 0.12 | 46.6 | 468 | 271 | 57.9 | 3186 | 29 | 199 | 10 | 21.2 | 5.1 |
| 18 | 6-J.Cutler | CHI | 17 | 1.17 | 56.6 | 0.07 | 0.09 | 45.8 | 474 | 282 | 59.5 | 3628 | 56 | 380 | 17 | 21.9 | 4.7 |
| 19 | 10-V.Young | TEN | 9 | 0.86 | 35.4 | 0.10 | 0.18 | 45.7 | 156 | 93 | 59.6 | 1255 | 13 | 80 | 3 | 32.7 | 6.2 |
| 20 | 3-J.Kitna | DAL | 10 | 0.60 | 42.3 | 0.06 | 0.11 | 48.2 | 318 | 209 | 65.7 | 2365 | 22 | 103 | 12 | 17.3 | 5.1 |
| 21 | 5-D.McNabb | WAS | 13 | 0.48 | 10.7 | 0.04 | 0.02 | 44.8 | 472 | 275 | 58.3 | 3377 | 37 | 271 | 15 | 18.9 | 4.8 |
| 22 | 5-B.Gradkowski | OAK | 6 | 0.22 | -11.2 | 0.04 | -0.06 | 42.4 | 158 | 83 | 52.5 | 1059 | 10 | 77 | 7 | 22.8 | 4.0 |
| 23 | 8-M.Hasselbeck | SEA | 16 | 0.17 | 4.2 | 0.01 | 0.01 | 46.7 | 525 | 314 | 59.8 | 3528 | 32 | 196 | 18 | 21.0 | 4.5 |
| 24 | 8-K.Orton | DEN | 13 | 0.12 | 50.3 | 0.01 | 0.09 | 44.8 | 498 | 293 | 58.8 | 3652 | 34 | 242 | 9 | 23.5 | 5.6 |
| 25 | 8-S.Bradford | SL | 16 | 0.09 | -10.2 | 0.01 | -0.02 | 42.9 | 590 | 354 | 60.0 | 3512 | 34 | 244 | 15 | 12.5 | 4.2 |
| 26 | 12-C.McCoy | CLV | 8 | -0.18 | 16.5 | -0.02 | 0.06 | 44.6 | 222 | 135 | 60.8 | 1576 | 23 | 132 | 9 | 20.3 | 4.2 |
| 27 | 11-A.Smith | SF | 11 | -0.18 | 0.2 | -0.02 | 0.00 | 41.4 | 342 | 204 | 59.6 | 2370 | 25 | 140 | 10 | 17.3 | 4.9 |
| 28 | 5-K.Collins | TEN | 10 | -0.23 | 30.6 | -0.02 | 0.10 | 46.2 | 278 | 160 | 57.6 | 1823 | 13 | 91 | 8 | 25.2 | 4.7 |
| 29 | 9-T.Romo | DAL | 6 | -0.23 | 30.8 | -0.04 | 0.13 | 49.0 | 213 | 148 | 69.5 | 1605 | 7 | 41 | 7 | 15.5 | 5.7 |
| 30 | 3-M.Moore | CAR | 6 | -0.38 | -26.2 | -0.06 | -0.16 | 43.3 | 143 | 79 | 55.2 | 857 | 13 | 90 | 10 | 25.9 | 2.0 |
| 31 | 14-Sh.Hill | DET | 11 | -0.51 | 46.5 | -0.05 | 0.10 | 47.5 | 416 | 257 | 61.8 | 2686 | 17 | 113 | 12 | 17.8 | 4.7 |
| 32 | 14-R.Fitzpatrick | BUF | 13 | -0.88 | 11.1 | -0.07 | 0.02 | 42.9 | 441 | 255 | 57.8 | 2992 | 23 | 145 | 15 | 22.0 | 4.7 |
| 33 | 3-D.Anderson | ARZ | 12 | -0.89 | -32.0 | -0.07 | -0.09 | 41.9 | 327 | 169 | 51.7 | 2065 | 25 | 176 | 10 | 26.0 | 4.1 |
| 34 | 4-K.Kolb | PHI | 7 | -1.02 | 4.4 | -0.15 | 0.02 | 46.0 | 189 | 115 | 60.8 | 1197 | 15 | 102 | 7 | 19.6 | 3.8 |
| 35 | 9-C.Palmer | CIN | 16 | -1.11 | 47.5 | -0.07 | 0.07 | 50.0 | 586 | 362 | 61.8 | 3970 | 26 | 201 | 20 | 17.7 | 4.7 |
| 36 | 7-C.Henne | MIA | 15 | -1.28 | 9.2 | -0.09 | 0.02 | 45.9 | 491 | 302 | 61.5 | 3298 | 30 | 178 | 18 | 17.1 | 4.4 |
| 37 | 4-B.Favre | MIN | 13 | -1.55 | -26.2 | -0.12 | -0.06 | 43.0 | 358 | 217 | 60.6 | 2509 | 21 | 139 | 19 | 21.2 | 4.0 |
| 38 | 17-J.Delhomme | CLV | 5 | -1.83 | -24.9 | -0.37 | -0.15 | 39.1 | 149 | 93 | 62.4 | 872 | 6 | 49 | 7 | 16.1 | 3.3 |
| 39 | 2-J.Clausen | CAR | 13 | -1.83 | -83.7 | -0.14 | -0.23 | 33.8 | 299 | 157 | 52.5 | 1558 | 33 | 223 | 9 | 16.1 | 2.8 |
